Ramos SV, Distefano G, Lui LY, Cawthon PM, Kramer P, Sipula IJ, Bello FM, Mau T, Jurczak MJ, Molina AJ, Kershaw EE, Marcinek DJ, Toledo FGS, Newman AB, Hepple RT, Kritchevsky SB, Goodpaster BH, Cummings SR, Coen PM. Role of Cardiorespiratory Fitness and Mitochondrial Energetics in Reduced Walk Speed of Older Adults with Diabetes in the Study of Muscle, Mobility and Aging (SOMMA). Diabetes. 2024 Mar 29; PMID: 37986814; PMCID: PMC10659460.
Duchowny KA, Marcinek DJ, Mau T, Diaz-Ramierz LG, Lui LY, Toledo FGS, Cawthon PM, Hepple RT, Kramer PA, Newman AB, Kritchevsky SB, Cummings SR, Coen PM, Molina AJ. Childhood adverse life events and skeletal muscle mitochondrial function. Sci Adv. 2024 Mar 8;10.
Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJ, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK. Calorie restriction reduces biomarkers of cellular senescence in humans. Aging Cell. 2024 Feb;23(2):e14038. doi: 10.1111/acel.14038
Schaich CL, Hughes TM, Kitzman DW, Jung Y, Chen H, Nicklas BJ, Houston DK, Brubaker PH, Molina AJ, Hugenschmidt CE. Neurocognitive Impairments and Their Improvement Following Exercise and Dietary Interventions in Older Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2024 Jan;17(1):e011134
Prajapati SK, Shah R, Alford N, Mishra SP, Jain S, Hansen B, Sanberg P, Molina AJ, Yadav H. The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer’s Disease. The Journals of Gerontology: Series A. 2023 Dec 1;78(12):2187-202.
Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJ, Redman LM, Martin CK, Racette SB, Huffman KM. Calorie restriction reduces biomarkers of cellular senescence in humans. Aging Cell. 2023 Nov 14:e14038.
Theresa Mau, Li-Yung Lui, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Frederico G S Toledo, Adam J Santanasto, Eric G Shankland, David J Marcinek, Michael J Jurczak, Ian Sipula, Fiona M Bello, Kate A Duchowny, Anthony J A Molina, Lauren M Sparks, Bret H Goodpaster, Russell T Hepple, Stephen B Kritchevsky, Anne B Newman, Peggy M Cawthon, Steven R Cummings, Paul M Coen, Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging, The Journals of Gerontology: Series A, Volume 78, Issue 8, August 2023, Pages 1367–1375, https://doi.org/10.1093/gerona/glac238
Shively, Carol A., Brett M. Frye, Jacob D. Negrey, Corbin SC Johnson, Courtney L. Sutphen, Anthony JA Molina, Hariom Yadav, Noah Snyder-Mackler, and Thomas C. Register. The Interactive Effects of Psychosocial Stress and Diet Composition on Health in Primates. Neuroscience & Biobehavioral Reviews (2023): 105320.
Gonzalez-Armenta, J. L., Bergstrom, J., Lee, J., Furdui, C. M., Nicklas, B. J., & Molina, A. J. (2023). Serum factors mediate changes in mitochondrial bioenergetics associated with diet and exercise interventions. GeroScience, 1-17.
Zeng L, Herdman DS, Lee SM, Tao A, Das M, Bertin S, Eckmann L, Mahata S, Wu P, Hara M, Byun JW, Devulapalli S, Patel HH, Molina AJ, Osborn O, Corr M, Raz E, Webster NJG. Loss of cAMP signaling in CD11c immune cells protects against diet-induced obesity. Diabetes. 2023 May 31:db221035. doi: 10.2337/db22-1035.
Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA. Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2023 May 10. doi: 10.1001/jamacardio.2023.0957.
Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 Mar 14:e111901. doi: 10.15252/embj.2022111901.
Mau T, Lui LY, Distefano G, Kramer PA, Ramos SV, Toledo FGS, Santanasto AJ, Shankland EG, Marcinek DJ, Jurczak MJ, Sipula I, Bello FM, Duchowny KA, Molina AJA, Sparks LM, Goodpaster BH, Hepple RT, Kritchevsky SB, Newman AB, Cawthon PM, Cummings SR, Coen PM. Mitochondrial energetics in skeletal muscle are associated with leg power and cardiorespiratory fitness in the Study of Muscle, Mobility, and Aging (SOMMA). J Gerontol A Biol Sci Med Sci. 2022 Dec 3:glac238. doi: 10.1093/gerona/glac238.
Brubaker PH, Nicklas BJ, Houston DK, Hundley WG, Chen H, Molina AJA, Lyles WM, Nelson B, Upadhya B, Newland R, Kitzman DW. A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2023 Feb;16(2):e010161. doi: 10.1161/CIRCHEARTFAILURE.122.010161.
Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 Oct 5. doi: 10.1038/s41586-022-05169-z.
Amick KA, Mahapatra G, Gao Z, Dewitt A, Craft S, Jain M, Molina AJA. Plasma glycocholic acid and linoleic acid identified as potential mediators of mitochondrial bioenergetics in Alzheimer's dementia. Front Aging Neurosci. 2022 Sep 23;14:954090. doi: 10.3389/fnagi.2022.954090. PMID: 36212044; PMCID: PMC9540364.
Mahapatra G, Gao Z, Bateman J, Lockhart SN, DeWitt AR, Piloso JE, Kramer PA, Gonzalez-Armenta J, Amick KA, Casanova R, Craft S, Molina AJ. Blood-Based Bioenergetic Profiling Reveals Differences in Mitochondrial Function Associated with Cognitive Performance and Alzheimer’s Disease. Alzheimer's Dement. 2022; 1- 13. https://doi.org/10.1002/alz.12731
Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJ. Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. Bioenergetics Communications. https://doi.org/10.26124/mitofit:2022-0007
Ding J, Lohman K, Molina A, Delbono O, Bertoni A, Shea S, Post W, Guo X, Barr RG, Manichaikul AW, Pankow JS, Rotter JI, Hoeschele I, Kritchevsky SB, Liu Y. The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA). Geroscience. 2022 Jun 23. doi: 10.1007/s11357-022-00608-1. Epub ahead of print. PMID: 35737188.
Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman KH, Neufer PD, Molina AJA, Ferrucci L, Picard M. Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis. FASEB J. 2022 Feb;36(2):e22146. doi: 10.1096/fj.202101628R. PMID: 35073429
Amick KA, Mahapatra G, Bergstrom J, Gao Z, Craft S, Register TC, Shively CA, Molina AJA. Brain region specific disruption of mitochondrial bioenergetics in cynomolgus macaques fed a Western vs. a Mediterranean diet. Am J Physiol Endocrinol Metab. 2021 Sep 27. PMID: 34569271
Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II and Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction. Journal of the American College of Cardiology. 2021;78:1166-1187. PMID: 34503685
Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJ, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 Aug 9. PMID: 34370163
Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proceedings of the National Academy of Sciences. 2021;118(23):e2025718118. doi: 10.1073/pnas.2025718118.
Gonzalez-Armenta JL, Li N, Lee RL, Lu B, Molina AJ, Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice, The Journals of Gerontology: Series A. 2020 Dec. Link
Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. Link
Ma L. Ainsworth H, Snipes J, Murea M, Choi Y, Langefeld C, Parks J, Bharadwaj M, Chou J, Hemal A, Petrovik S, Craddock A, Cheng D, Hawkins G, Miller L, Hicks P, Saleem M, Divers J, Molina AJ, Freedman B. APOL1 kidney-risk variants induce mitochondrial fission. Kidney Int Rep. 2020 Jun; 5(6):891-904. Link
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Mitochondrial GTP Links Nutrient Sensing to beta Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019;28(3):759-72 e10. doi: 10.1016/j.celrep.2019.06.058. PubMed PMID: 31315053. Link
Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJ. Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a Western versus Mediterranean diet. The Journal of Nutrition, Volume 149, Issue 9, September 2019, Pages 1493–1502, https://doi.org/10.1093/jn/nxz092
Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina AJ, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D. Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight. 2019. doi: 10.1172/jci.insight.126688. PubMed PMID: 30777938.
Mahapatra G, Smith C, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJ. Blood based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes, Clinical Science. Nov 2018, CS20180690; DOI: 10.1042/CS20180690
Holmila R, Vance S, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole L, King B, Furdui C. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Reports. 2018;8:6635. doi:10.1038/s41598-018-24493-x.
Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively CA, Andrews R, Neth B, Keene CD, Mintz A, Craft S, Molina AJ. (2017) Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxidative Medicine and Cellular Longevity 2017:7317251. doi: 10.1155/2017/7317251.
Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI. APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction. J. Am. Soc. Nephrol. 2017;28(4):1093-1105.
Kavanagh K, Davis AT, Peters DE, LeGrand AC, Bharadwaj MS, Molina AJ. Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys. Obesity (Silver Spring, Md.). 2017;25(4):689-696.
Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biology. 2016;10:65-77.
Molina AJ, Bharadwaj MS, Van Horn C, et al. Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC. Heart failure. 2016;4(8):636-645.
Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp. Gerontol. 2015;70:84-91.
Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J. Gerontol. A Biol. Sci. Med. Sci. 2015;70(11):1394-1399.
Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM. Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Radiat. Res. 2015;183(3):291-304.
Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J. Biol. Chem. 2015;290(1):396-408.
Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. Journal of visualized experiments : JoVE. 2015(96).
Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC obesity. 2015;2:40.
Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biology. 2014;2:1008-1015.
Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci. Transl. Med. 2013;5(192):192ra185.
Lovy A, Molina AJ, Cerqueira FM, Trudeau K, Shirihai OS. A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. Journal of visualized experiments : JoVE. 2012(65):e3991.
Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012;7(1):e31074.
Trudeau K, Molina AJ, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest. Ophthalmol. Vis. Sci. 2011;52(12):8657-8664.
Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnoczky G, Shirihai OS. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am. J. Physiol. Cell Physiol. 2010;299(2):C477-487.
Trudeau K, Molina AJ, Guo W, Roy S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am. J. Pathol. 2010;177(1):447-455.
Molina AJ, Wikstrom JD, Stiles L, et al. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009;58(10):2303-2315.
Molina AJ, Shirihai OS. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009;457:289-304.
Twig G, Elorza A, Molina AJ, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008;27(2):433-446.
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat. Med. 2008;14(2):144-153.
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007;56(10):2569-2578.
Kreitzer MA, Collis LP, Molina AJ, Smith PJ, Malchow RP. Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate. J. Gen. Physiol. 2007;130(2):169-182.
Molina AJ, Verzi MP, Birnbaum AD, et al. Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate. J. Physiol. 2004;560(Pt 3):639-657.
Molina AJ, Hammar K, Sanger R, Smith PJ, Malchow RP. Intracellular release of caged calcium in skate horizontal cells using fine optical fibers. Biol. Bull. 2003;205(2):215-216.
Molina AJ, Smith PJ, Malchow RP. Hydrogen ion fluxes from isolated retinal horizontal cells: modulation by glutamate. Biol. Bull. 2000;199(2):168-170.
Invited Publications
Molina, AJ (2017) Blood-Based Bioenergetic Profiling: a readout of systemic bioenergetic capacity that is related to differences in body composition. Redox Biology, In Press *Invited editorial commentary
Haigh, S. E., Twig, G., Molina, AJ, Wikstrom, J. D., Deutsch, M. & Shirihai, O. S. (2007). PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found. Symp., 287, 21-36.
Miscellaneous Publications
-The protonmotive force and respiratory control: Building blocks of mitochondrial physiology.
http://www.mitoeagle.org/images/5/5b/MitoEAGLE_preprint_2017-09-21.pdf
Anthony Molina, Jenny Collins, and Daniel Tyrrell are included as contributing authors.
-Collaborative Innovation is Key: Anthony Molina, Open Thinking People’s Choice Award Winner
-Adding Life To Your Years...
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