Wellcome Leap Dynamic Resilience

Resilience, defined as the ability to recover from the adverse effects of physiological stressors, diminishes with advancing age, coinciding with the time of life when the risk for encountering stressors increases significantly. While previous efforts to define successful aging highlight avoidance of illness as a hallmark, more recent definitions highlight resilience as a defining factor. Despite the recognition that resilience is key to healthy longevity across multiple domains, reliable markers of dynamic resilience remain elusive.

-We are currently developing and validating blood-based signatures of universal resilience using: 1) a rich biospecimen and data repository from one of the longest observational cohort studies in existence, 2) multi-omic approaches and state of the art data science techniques, and 3) a real-world clinical setting treating the common physiological stress events (SEs) facing older adults.

-We are seeking to identify universal signatures of resilience that are applicable to the common SEs that impact older adults.